Why Dogs?
At Reveal, we have decided to use dogs as our primary test subjects. There are many good reasons for this; but there are two primary reasons:
1. Dogs carry a similar spectrum of cancer to that of man; and,
2. When compared to a mouse, a dog's immune system much more closely resembles our own.
There are also some good secondary reasons Dogs are a better choice:
1. Over 1,000,000 dogs get cancer each year, and "Man's Best Friend" deserves a solution.
2. All these dogs could immediately benefit from Reveal's BioPACK, allowing us to establish a track record very quickly.
3. A dog's body mass and blood volume make all this activity directly applicable to humans.
1. The immune system similarity is much greater in dogs, than in mice.
2. A number of applications, which have worked in mice, have NOT transferred successfully into humans
3. Mice are too small for effective volume comparisons in safety testing.
One of the most important reasons for choosing dogs, instead of mice, has to do with size. Mice are simply too small to use for the extensive safety testing we will conduct on our BioPACK device. We need an animal with a sufficient blood volume to ensure that the volume of blood in the BioPACK device is only a small fraction of the total blood volume of the animal, as it will be in humans.
1. Dogs carry a similar spectrum of cancer to that of man; and,
2. When compared to a mouse, a dog's immune system much more closely resembles our own.
There are also some good secondary reasons Dogs are a better choice:
1. Over 1,000,000 dogs get cancer each year, and "Man's Best Friend" deserves a solution.
2. All these dogs could immediately benefit from Reveal's BioPACK, allowing us to establish a track record very quickly.
3. A dog's body mass and blood volume make all this activity directly applicable to humans.
Why Not Mice First?
Traditionally, most medical research starts out with mice as their test models. Some folks may wonder why we at Reveal have NOT chosen to use mice. There are a few important reasons why mice are NOT the best choice for Reveal's approach:1. The immune system similarity is much greater in dogs, than in mice.
2. A number of applications, which have worked in mice, have NOT transferred successfully into humans
3. Mice are too small for effective volume comparisons in safety testing.
One of the most important reasons for choosing dogs, instead of mice, has to do with size. Mice are simply too small to use for the extensive safety testing we will conduct on our BioPACK device. We need an animal with a sufficient blood volume to ensure that the volume of blood in the BioPACK device is only a small fraction of the total blood volume of the animal, as it will be in humans.
